Transient Reversal of the Sodium - Calcium Exchanger Boosts Presynaptic Calcium and 1 Synaptic Transmission at a Cerebellar Synapse

Transient Reversal of the Sodium-Calcium Exchanger Boosts Presynaptic Calcium and 1 Synaptic Transmission at a Cerebellar Synapse 2 Chris J. Roome, Emmet M. Power and Ruth M. Empson 3 4 Department of Physiology, Brain Health Research Centre, Otago School of Medical Sciences, 5 University of Otago, Dunedin, New Zealand 6 7 Running Head: Reversal of Na/Ca exchanger at synapses 8 9 *Corresponding author: 10 Ruth Empson, Department of Physiology, Otago School of Medical Sciences, University of 11 Otago, PO Box 913, Dunedin, New Zealand. 12 Phone: +64 3 479 7464 13 Fax: +64 3 479 7323 14 Email: [email protected] 15 16 Conflict of Interest 17 The authors declare no competing financial interests. 18 Author Contributions 19 CJR, EMP and RME designed the work, performed experiments and analysed the data. All 20 authors discussed the results, wrote the manuscript and approved the final version of the 21 manuscript. 22 23 Acknowledgements 24 We acknowledge support from the Neurological Foundation of New Zealand, a University of 25 Otago Research Grant and University of Otago PhD Scholarship to CJR and a Department of 26 Physiology AIM Grant. We thank Drs Stephen Bunn and Istvan Abraham for the kind 27 donation of PC12 cells and Dr Kajsa Igelström for constructive comments on the manuscript. 28